POLYDATIN-INDUCED CELL APOPTOSIS AND CELL CYCLE ARREST ARE POTENTIATED BY JANUS KINASE 2 INHIBITION IN LEUKEMIA CELLS

POLYDATIN-INDUCED CELL APOPTOSIS AND CELL CYCLE ARREST ARE POTENTIATED BY JANUS KINASE 2 INHIBITION IN LEUKEMIA CELLS

Polydatin (PD), a natural precursor of resveratrol, has a variety of biological activities, including anti‑tumor effects. However, the underlying molecular mechanisms of the anti-cancer activity of PD has not been fully elucidated. The present study demonstrated that PD significantly inhibited the proliferation of the MOLT-4 leukemia cell line in a dose‑ and time-dependent manner by using Cell Counting Kit‑8 assay…

 

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