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Sirtuins or Sirt2 proteins constitute a class of proteins with enzymatic activity; they operate as histone deacetylases or mono-ribosyltransferases. Sirtuins regulate important metabolic pathways in prokaryotes and eukaryotes. The name is derived from a regulatory silencing yeast gene implicated in the regulation of cell development. Sirtuins mediate phenomena such as aging, transcriptional regulation, apoptosis, stress resistance, and also affect energy efficiency and vigilance during low calorie situations (caloric restriction).

SIRT500 Plus is a dietary supplement containing the extracts of some plants rich in SIRT activators (called STACS). SIRT500 Plus is designed to provide daily doses of selected SIRT activators, with the aim of stimulating constant cell renewal as it already happens in a young organism. The composition of SIRT500 Plus is designed to replace the daily intake of fruits and vegetables containing enough STACS to promote cell renewal, an amount otherwise difficult to consume in the everyday diet. For example: to consume the relevant amount of a substance capable of stimulating the production of SIRT 1 and SIRT 2, one would need to consume 5-6 pounds of blueberries and 5 liters of fresh pomegranate juice daily. SIRT500 Plus is designed to ensure the constant presence of SIRT molecules-activators in the human body with slowed absorption in order to have the anti-aging and immune defense effects prolonged throughout the day. SIRT500 Plus contains natural extracts that in their maximum synergy are able to promote the production of all the sirtuins (SIRT - 1,2,3,4,5,6,7), increasing the level of their presence in the body from 3 to 14 times. In SIRT500 Plus there is Polydatin (stilbenoid glycoside derived from Resveratrol), whose effectiveness is documented in many scientific researches. The formula of SIRT500 Plus provides for the targeted intervention in order to stimulate the continuous renewal of healthy cells of the nervous system as well as of the skin, bone tissue, muscles and internal organs. The maintenance of high sirtuin levels promotes a responsive and efficient immune system. SIRT500 Plus also provides the ingredients and substances such as vitamins, antioxidants and elements, which promote the effective absorption of these substances from the human digestive tract.

Many anti-aging products on the market are focused on aesthetic and cosmetic treatments, while SIRT500 Plus, the dietary supplement developed on the basis of world-class scientific research, acts at a systemic level throughout the body.

SIRT500 Plus activates the natural production process of sirtuins (Sirt 1-7) and acts at the cellular level. It is a natural product, designed to provide the human organism with substances that promote the healthy replication of all tissue cells. SIRT500 Plus acts in a gradual way, favoring the renewal of the cells and respecting the natural calendar of substitution of the old cells with the new ones. The composition of SIRT500 Plus provides ingredients necessary for the activation of the metabolism and for the rejuvenation of every single cell of the human body, eliminating toxins and harmful residues which accumulate in the cells during life and which are responsible for premature aging. SIRT500 Plus promotes the "reprogramming" of cells, aiding longevity and providing protection from age-related diseases.

SIRT500 Plus has no contraindications except for those allergic to the active ingredients of the product. In this case or in the case of individuals with chronic or serious diseases, such as cancer or hemophilia, it is recommended to consult your doctor before the constant intake of SIRT500 Plus.

Two tablets daily, in the morning and evening.

SIRT500 Plus is designed to strengthen the immune system and protect the human body from age-related diseases. It provides certain foods, in the form of extracts, which could hardly be taken following any diet. SIRT500 Plus is a dietary supplement, not a medicine, in case of disease you should always seek medical advice.

Sirtuin production begins to decline after the age of 30-35. It would therefore be advisable to supplement your diet with SIRT500 Plus around this age.

From the clinical tests performed, the prolonged and continuous use of SIRT500 Plus rejuvenates all the cells of the human body, including neurons. Decreasing biological age by 15-40% by extending human life expectancy is now possible, while still following a healthy lifestyle.

The perception of changes linked to the constant and prolonged intake of SIRT500 Plus is entirely individual. In elderly subjects the effects are already perceived during the first week of intake, while in younger healthy subjects, the first beneficial effects can be obtained in the first 4/8 weeks. The first beneficial effects are:

- improved sleep;
- increased resistance to psycho-physical stress;
- more physical and mental energy.

SIRT500 Plus can be taken either on an empty or full stomach.

Each tablet of SIRT500 Plus is composed of natural plant extracts such as blueberry, pomegranate, magnolia with the addition of some minerals and B group vitamin (RDA). There are no expected side effects other than those from allergies to the above foods.

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